Seeing the Light: CAR T-cell Targeting of Lambda-restricted B-cell Lymphomas.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 34417197.
- Also identified by DOI 10.1158/1078-0432.CCR-21-1450.
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Abstract
CD19-targeted chimeric antigen receptor T cells eliminate both malignant and normal B cells. Targeting immunoglobulin light chains instead of CD19 could preserve half of the normal B cells and provide an alternative target.<i>See related article by Ranganathan et al., p. 5951</i>.
Medical subject headings
- Lymphoma, B-Cell
- T-Lymphocytes