EXPLORing exosomes for the treatment of acute kidney injury.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 34420658.
- Also identified by DOI 10.1016/j.kint.2021.05.039.
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Abstract
Exosomes are emerging as a novel drug delivery system for the treatment of numerous diseases, including acute kidney injury. In this issue of Kidney International, Kim et al. use a novel optogenetically engineered exosome technology, "EXPLOR," to deliver the exosomal repressor of nuclear factor-κB into mice before and after renal ischemia-reperfusion. They report that these exosomes downregulated renal nuclear factor-κB signaling and ameliorated acute kidney injury. This study deserves attention for its significant scientific and potential clinical value in acute kidney injury.
Medical subject headings
- Acute Kidney Injury
- Exosomes
- Reperfusion Injury