Intestinal lymphatic dysfunction: a new pathway mediating gut-kidney crosstalk in kidney disease.
Level V
Where this comes from
- Record sourced from PubMed, PMID 34420659.
- Also identified by DOI 10.1016/j.kint.2021.06.022.
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Abstract
The importance of kidney-gut crosstalk in driving kidney disease complications is increasingly being realized. However, little attention has been given to intestinal lymphatic changes in kidney disease. Zhong et al. report striking changes to intestinal lymphatic composition, structure, and function in proteinuric kidney injury models, including increased lymphangiogenesis, lymph flow, and transport of lipoproteins and proinflammatory mediators. These changes appear to be stimulated by isolevuglandin (IsoLG)-modified apolipoprotein AI (ApoAI). This intestinal lymphatic response may regulate systemic complications.
Medical subject headings
- Gastrointestinal Diseases
- Kidney Diseases
- Lymphatic Vessels