HeTDR: Drug repositioning based on heterogeneous networks and text mining.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34430926.
- Also identified by DOI 10.1016/j.patter.2021.100307 and PMC identifier 8369234.
- Licence recorded as CC BY-NC-ND.
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Abstract
Using existing knowledge to carry out drug-disease associations prediction is a vital method for drug repositioning. However, effectively fusing the biomedical text and biological network information is one of the great challenges for most current drug repositioning methods. In this study, we propose a drug repositioning method based on heterogeneous networks and text mining (HeTDR). This model can combine drug features from multiple drug-related networks, disease features from biomedical corpora with the known drug-disease associations network to predict the correlation scores between drug and disease. Experiments demonstrate that HeTDR has excellent performance that is superior to that of state-of-the-art models. We present the top 10 novel HeTDR-predicted approved drugs for five diseases and prove our model is capable of discovering potential candidate drugs for disease indications.