A protein regulated by UBE3A PEGs a potential biomarker.
basic_science · Level V
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- Record sourced from PubMed, PMID 34467252.
- Also identified by DOI 10.1016/j.xcrm.2021.100377 and PMC identifier 8385320.
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Abstract
New research from Pandya and colleagues<sup>1</sup> identifies PEG10 as a UBE3A-regulated protein that may underlie pathophysiology in Angelman syndrome neurons. PEG10 is a secreted protein, and this work suggests that it may be a potential biomarker for Angelman syndrome therapeutics under development.
Medical subject headings
- Angelman Syndrome
- Ubiquitin-Protein Ligases