Type I, II, and III Interferon Signatures Correspond to Coronavirus Disease 2019 Severity.
Where this comes from
- Record sourced from PubMed, PMID 34467988.
- Also identified by DOI 10.1093/infdis/jiab288 and PMC identifier 8244575.
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Abstract
We analyzed plasma levels of interferons (IFNs) and cytokines, and expression of IFN-stimulated genes in peripheral blood mononuclear cells in patients with coronavirus disease 2019 of varying disease severity. Patients hospitalized with mild disease exhibited transient type I IFN responses, while intensive care unit patients had prolonged type I IFN responses. Type II IFN responses were compromised in intensive care unit patients. Type III IFN responses were induced in the early phase of infection, even in convalescent patients. These results highlight the importance of early type I and III IFN responses in controlling coronavirus disease 2019 progression.
Medical subject headings
- COVID-19
- Interferon Type I
- Interferon-gamma
- Interferons