Association of E484K Spike Protein Mutation With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Vaccinated Persons: Maryland, January-May 2021.

Feder, Kenneth A; Patel, Ami; Vepachedu, Venkata R; Dominguez, Catherine; Keller, Eric N; Klein, Liore; Kim, Curi; Blood, Tim et al. · Clin Infect Dis · 2022

retrospective_cohort · Level III

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Abstract

Among 9048 people infected with SARS-CoV-2 between January and May 2021 in Maryland, in regression-adjusted analysis, SARS-CoV-2 viruses carrying the spike protein mutation E484K were disproportionately prevalent among persons infected after full vaccination against COVID-19 compared with infected persons who were not fully vaccinated (aOR, 1.96; 95% CI: 1.36-2.83).

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