Ex situ machine preservation of donor livers for transplantation: HOPE for all?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 34476463.
- Also identified by DOI 10.1093/bjs/znab293 and PMC identifier 10364854.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Hypothermic oxygenated machine perfusion (HOPE) reduces ischaemia–reperfusion injury of donor livers and thereby improves outcomes after transplantation. End-ischaemic normothermic machine perfusion (NMP) enables assessment of hepatobiliary viability and selection of livers that would otherwise have been declined for transplantation. We advocate the combined use of (dual) HOPE and NMP for livers that are considered high risk, but may still be transplanted safely after <i>ex situ</i> resuscitation and assessment of hepatobiliary viability. Combined dual HOPE–NMP has the potential to substantially decrease the high rates of deceased donor liver discard.
Medical subject headings
- Liver Transplantation
- Organ Preservation