Sleep Deprivation Exacerbates Seizures and Diminishes GABAergic Tonic Inhibition.
basic_science · Level V
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- Record sourced from PubMed, PMID 34476841.
- Also identified by DOI 10.1002/ana.26208 and PMC identifier 8530964.
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Abstract
Patients with epilepsy report that sleep deprivation is a common trigger for breakthrough seizures. The basic mechanism of this phenomenon is unknown. In the Kv1.1<sup>-/-</sup> mouse model of epilepsy, daily sleep deprivation indeed exacerbated seizures though these effects were lost after the third day. Sleep deprivation also accelerated mortality in ~ 52% of Kv1.1<sup>-/-</sup> mice, not observed in controls. Voltage-clamp experiments on the day after recovery from sleep deprivation showed reductions in GABAergic tonic inhibition in dentate granule cells in epileptic Kv1.1<sup>-/-</sup> mice. Our results suggest that sleep deprivation is detrimental to seizures and survival, possibly due to reductions in GABAergic tonic inhibition. ANN NEUROL 2021;90:840-844.
Medical subject headings
- Epilepsy
- Receptors, GABA-A
- Seizures
- Sleep Deprivation