Inflation comes before the fall: How epithelial stretch drives crypt fission.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 34478627.
- Also identified by DOI 10.1016/j.stem.2021.08.008.
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Abstract
In this issue of Cell Stem Cell, Tallapragada et al. (2021) present an intestinal organoid culture system for high-throughput live imaging to investigate niche-independent mechanisms of crypt fission. They find that Piezo activity downregulates Lgr5 expression in stretched epithelial cells within inflated organoids, which form multiple new crypts upon collapse.
Medical subject headings
- Epithelial Cells
- Organoids