The genetics of testosterone contributes to "femaleness/maleness" of cardiometabolic traits and type 2 diabetes.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 34480103.
- Also identified by DOI 10.1038/s41366-021-00960-w.
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Abstract
The genetic architecture of testosterone is highly distinct between sexes. Moreover, obesity is associated with higher testosterone in females but lower testosterone in males. Here, we ask whether male-specific testosterone variants are associated with a male pattern of obesity and type 2 diabetes (T2D) in females, and vice versa. In the UK Biobank, we conducted sex-specific genome-wide association studies and computed polygenic scores for total (PGS<sub>TT</sub>) and bioavailable testosterone (PGS<sub>BT</sub>). We tested sex-congruent and sex-incongruent associations between sex-specific PGS<sub>T</sub>s and metabolic traits, as well as T2D diagnosis. Female-specific PGS<sub>BT</sub> was associated with an elevated cardiometabolic risk and probability of T2D, in both sexes. Male-specific PGS<sub>TT</sub> was associated with traits conferring a lower cardiometabolic risk and probability of T2D, in both sexes. We demonstrate the value in considering polygenic testosterone as sex-related continuous traits, in each sex.
Medical subject headings
- Diabetes Mellitus, Type 2
- Metabolic Syndrome
- Sex Differentiation
- Testosterone