Growth-coupled selection of synthetic modules to accelerate cell factory development.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34489458.
- Also identified by DOI 10.1038/s41467-021-25665-6 and PMC identifier 8421431.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Synthetic biology has brought about a conceptual shift in our ability to redesign microbial metabolic networks. Combining metabolic pathway-modularization with growth-coupled selection schemes is a powerful tool that enables deep rewiring of the cell factories’ biochemistry for rational bioproduction.
Medical subject headings
- Escherichia coli
- Metabolic Engineering
- Saccharomycetales
- Synthetic Biology