Glucocorticoid resistance and hyperlactatemia: A tag team to worsen sepsis.
Level V
Where this comes from
- Record sourced from PubMed, PMID 34496226.
- Also identified by DOI 10.1016/j.cmet.2021.08.007 and PMC identifier 9059133.
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Abstract
Glucocorticoid resistance often dims glucocorticoid's therapeutic efficacy in sepsis. However, the mechanism is incompletely understood. In this issue, Vandewalle et al. (2021) demonstrate that glucocorticoid resistance leads to hyperlactatemia and that this combination facilitates lethal sepsis. This insight gives important clarity to the pathophysiology of sepsis, while further suggesting therapeutic avenues for its treatment.
Medical subject headings
- Hyperlactatemia
- Metabolism, Inborn Errors
- Sepsis