T cells critically depend on pyruvate oxidation.
Level V
Where this comes from
- Record sourced from PubMed, PMID 34496227.
- Also identified by DOI 10.1016/j.cmet.2021.08.010.
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Abstract
Supporting the notion that cell lineage is a key determinant of cancer cell metabolism, Jun et al. (2021) identify a selective requirement for pyruvate dehydrogenase (PDH) activity in T cells and T cell leukemia, but not hematopoietic stem cells (HSCs) or myeloid leukemia, in this issue of Cell Metabolism.
Medical subject headings
- Pyruvate Dehydrogenase Complex
- T-Lymphocytes