Modelling the impact of lockdown-easing measures on cumulative COVID-19 cases and deaths in England.

Abstract

To assess the potential impacts of successive lockdown-easing measures in England, at a point in the COVID-19 pandemic when community transmission levels were relatively high. We developed a Bayesian model to infer incident cases and reproduction number (<i>R</i>) in England, from incident death data. We then used this to forecast excess cases and deaths in multiple plausible scenarios in which <i>R</i> increases at one or more time points. England. Publicly available national incident death data for COVID-19 were examined. Excess cumulative cases and deaths forecast at 90 days, in simulated scenarios of plausible increases in <i>R</i> after successive easing of lockdown in England, compared with a baseline scenario where <i>R</i> remained constant. Our model inferred an <i>R</i> of 0.75 on 13 May when England first started easing lockdown. In the most conservative scenario modelled where <i>R</i> increased to 0.80 as lockdown was eased further on 1 June and then remained constant, the model predicted an excess 257 (95% CI 108 to 492) deaths and 26 447 (95% CI 11 105 to 50 549) cumulative cases over 90 days. In the scenario with maximal increases in <i>R</i> (but staying ≤1), the model predicts 3174 (95% CI 1334 to 6060) excess cumulative deaths and 421 310 (95% CI 177 012 to 804 811) cases. Observed data from the forecasting period aligned most closely to the scenario in which <i>R</i> increased to 0.85 on 1 June, and 0.9 on 4 July. When levels of transmission are high, even small changes in <i>R</i> with easing of lockdown can have significant impacts on expected cases and deaths, even if <i>R</i> remains ≤1. This will have a major impact on population health, tracing systems and healthcare services in England. Following an elimination strategy rather than one of maintenance of <i>R</i> ≤1 would substantially mitigate the impact of the COVID-19 epidemic within England.