Asthma and Three Colinear Comorbidities: Obesity, OSA, and GERD.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 34506967.
- Also identified by DOI 10.1016/j.jaip.2021.09.003 and PMC identifier 8578370.
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Abstract
Asthma is a complex disease with heterogeneous phenotypes and endotypes that are incompletely understood. Obesity, obstructive sleep apnea, and gastroesophageal reflux disease co-occur in patients with asthma at higher rates than in those without asthma. Although these diseases share risk factors, there are some data suggesting that these comorbidities have shared inflammatory pathways, drive the development of asthma, or worsen asthma control. This review discusses the epidemiology, pathophysiology, management recommendations, and key knowledge gaps of these common comorbidities.
Medical subject headings
- Asthma
- Gastroesophageal Reflux
- Sleep Apnea, Obstructive