Mitigation of <i>Pseudomonas syringae</i> virulence by signal inactivation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34516871.
- Also identified by DOI 10.1126/sciadv.abg2293 and PMC identifier 8442906.
- Licence recorded as CC BY-NC.
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Abstract
<i>Pseudomonas syringae</i> is an important plant pathogen of many valuable crops worldwide, with more than 60 identified pathovars. The phytotoxins produced by these organisms were related to the severity of the damage caused to the plant. An emerging strategy to treat bacterial infections relies on interference with their signaling systems. In this study, we investigated <i>P. syringae</i> pv. <i>syringae</i>, which produces the virulence factor mangotoxin that causes bacterial apical necrosis on mango leaves. A previously unknown signaling molecule named leudiazen was identified, determined to be unstable and volatile, and responsible for mangotoxin production. A strategy using potassium permanganate, compatible with organic farming, was developed to degrade leudiazen and thus to attenuate the pathogenicity of <i>P. syringae</i> pv. <i>syringae</i>.