Background synaptic input modulates the visuospatial working memory.

Abstract

It is generally thought that persistent firing of neurons in the prefrontal cortex underlies working memory. Previous studies have focused on the influence of recurrent synaptic connectivity in local circuits on memory storage. Given neurons in the neocortex are extensively connected, individual neural circuits should receive synaptic inputs from other areas. Here we explore how background synaptic inputs (BSIs) modulate the visuospatial working memory in an oculomotor delayed response task. In a local recurrent network composed of pyramidal cells and interneurons, a bump attractor persists across the delay period, encoding the cue location. Under independent BSIs, the spontaneous network state before the cue presentation can be classified as inactive, active, or overactive, occurring successively with increasing the BSI strength, and the active state facilitates the memory storage. Under spatially correlated BSIs, optimal scenarios, in terms of accuracy of representation and resistance to distraction, involve the BSIs with intermediate strength and low correlation or high strength and moderate correlation. Our results demonstrate how the memory storage is regulated via tuning the balance between local excitation and global inhibition in the network. The current work reveals the functional importance of background input and suggests that robust memory storage could be accomplished over a variety of network states.