Comment on "Aberrant type 1 immunity drives susceptibility to mucosal fungal infections".
editorial · Level V
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- Record sourced from PubMed, PMID 34529474.
- Also identified by DOI 10.1126/science.abi6235.
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Abstract
Break <i>et al</i>. (Research Articles, 15 January 2021, eaay5731) conclude that T cell overproduction of interferon-γ causes chronic mucocutaneous candidiasis (CMC), a typical early feature of autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED). This contradicts studies implicating interleukin IL-17 and IL-22 deficiencies as a cause of CMC. We propose that Break <i>et al</i>. have focused on late-arising events rather than more common primary causes of CMC.
Medical subject headings
- Mycoses