Response to Comments on "Aberrant type 1 immunity drives susceptibility to mucosal fungal infections".
other · Level V
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- Record sourced from PubMed, PMID 34529475.
- Also identified by DOI 10.1126/science.abi8835 and PMC identifier 10120387.
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Abstract
Puel and Casanova and Kisand <i>et al</i>. challenge our conclusions that interferonopathy and not IL-17/IL-22 autoantibodies promote candidiasis in autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy. We acknowledge that conclusive evidence for causation is difficult to obtain in complex human diseases. However, our studies clearly document interferonopathy driving mucosal candidiasis with intact IL-17/IL-22 responses in <i>Aire</i>-deficient mice, with strong corroborative evidence in patients.
Medical subject headings
- Immunity, Mucosal
- Mycoses