A Guide to ComBat Harmonization of Imaging Biomarkers in Multicenter Studies.
Where this comes from
- Record sourced from PubMed, PMID 34531263.
- Also identified by DOI 10.2967/jnumed.121.262464 and PMC identifier 8805779.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The impact of PET image acquisition and reconstruction parameters on SUV measurements or radiomic feature values is widely documented. This scanner effect is detrimental to the design and validation of predictive or prognostic models and limits the use of large multicenter cohorts. To reduce the impact of this scanner effect, the ComBat method has been proposed and is now used in various contexts. The purpose of this article is to explain and illustrate the use of ComBat based on practical examples. We also give examples in which the ComBat assumptions are not met and, thus, in which ComBat should not be used.
Medical subject headings
- Positron-Emission Tomography
- Tomography, X-Ray Computed