Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34531396.
- Also identified by DOI 10.1038/s41467-021-25383-z and PMC identifier 8445967.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Implant related infections are the most common cause of joint arthroplasty failure, requiring revision surgeries and a new implant, resulting in a cost of $8.6 billion annually. To address this problem, we created a class of coating technology that is applied in the operating room, in a procedure that takes less than 10 min, and can incorporate any desired antibiotic. Our coating technology uses an in situ coupling reaction of branched poly(ethylene glycol) and poly(allyl mercaptan) (PEG-PAM) polymers to generate an amphiphilic polymeric coating. We show in vivo efficacy in preventing implant infection in both post-arthroplasty infection and post-spinal surgery infection mouse models. Our technology displays efficacy with or without systemic antibiotics, the standard of care. Our coating technology is applied in a clinically relevant time frame, does not require modification of implant manufacturing process, and does not change the implant shelf life.
Medical subject headings
- Anti-Bacterial Agents
- Coated Materials, Biocompatible
- Point-of-Care Systems
- Prosthesis-Related Infections
- Staphylococcal Infections
- Staphylococcus aureus