Osteogenesis and angiogenesis of a bulk metallic glass for biomedical implants.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34541400.
- Also identified by DOI 10.1016/j.bioactmat.2021.06.018 and PMC identifier 8424448.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Implantation is an essential issue in orthopedic surgery. Bulk metallic glasses (BMGs), as a kind of novel materials, attract lots of attentions in biological field owing to their comprehensive excellent properties. Here, we show that a Zr<sub>61</sub>Ti<sub>2</sub>Cu<sub>25</sub>Al<sub>12</sub> (at. %) BMG (Zr-based BMG) displays the best cytocompatibility, pronounced positive effects on cellular migration, and tube formation from <i>in-vitro</i> tests as compared to those of commercial-pure titanium and poly-ether-ether-ketone. The <i>in-vivo</i> micro-CT and histological evaluation demonstrate the Zr-based BMG can significantly promote a bone formation. Immunofluorescence tests and digital reconstructed radiographs manifest a stimulated effect on early blood vessel formation from the Zr-based BMG. Accordingly, the intimate connection and coupling effect between angiogenesis and osteogenesis must be effective during bone regeneration after implanting Zr-based BMG. Dynamic gait analysis in rats after implanting Zr-based BMG demonstrates a tendency to decrease the pain level during recovery, simultaneously, without abnormal ionic accumulation and inflammatory reactions. Considering suitable mechanical properties, we provide a realistic candidate of the Zr<sub>61</sub>Ti<sub>2</sub>Cu<sub>25</sub>Al<sub>12</sub> BMG for biomedical applications.