Phosphobisaromatic motifs enable rapid enzymatic self-assembly and hydrogelation of short peptides.
basic_science · Level V
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- Record sourced from PubMed, PMID 34545895.
- Also identified by DOI 10.1039/d1sm01221e and PMC identifier 8600407.
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Abstract
Enzyme-instructed self-assembly (EISA) and hydrogelation is a versatile approach for generating soft materials. Most of the substrates for alkaline phosphatase catalysed EISA utilize phosphotyrosine (<sub>p</sub>Tyr) as the enzymatic trigger for EISA and hydrogelation. Here we show the first example of phosphonaphthyl (<sub>p</sub>NP) and phosphobiphenyl (<sub>p</sub>BP) motifs acting as faster enzymatic triggers than phosphotyrosine for EISA and hydrogelation. This work illustrates novel enzyme triggers for rapid enzymatic self-assembly and hydrogelation.
Medical subject headings
- Hydrogels
- Peptides