Total and Unbound Doravirine Concentrations and Viral Suppression in CSF.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 34549268.
- Also identified by DOI 10.1093/cid/ciab835.
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Abstract
We determined total and unbound concentrations of doravirine (DOR) in cerebrospinal fluid and blood plasma. Total and unbound DOR concentrations in cerebrospinal fluid exceeded the half-maximal effective concentration against wild-type virus (5.1 ng/mL) in all patients, suggesting that DOR may contribute to inhibit viral replication in this compartment.
Medical subject headings
- HIV Infections
- HIV-1