Mathematical Modeling of Endemic Cholera Transmission.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34550373.
- Also identified by DOI 10.1093/infdis/jiab472 and PMC identifier 8687074.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Mathematical modeling can be used to project the impact of mass vaccination on cholera transmission. Here, we discuss 2 examples for which indirect protection from mass vaccination needs to be considered. In the first, we show that nonvaccinees can be protected by mass vaccination campaigns. This additional benefit of indirect protection improves the cost-effectiveness of mass vaccination. In the second, we model the use of mass vaccination to eliminate cholera. In this case, a high population level of immunity, including contributions from infection and vaccination, is required to reach the "herd immunity" threshold needed to stop transmission and achieve elimination.
Medical subject headings
- Cholera
- Cholera Vaccines
- Health Promotion
- Immunity, Herd
- Mass Vaccination