Autocrine and paracrine effects of a novel podocyte gene, RARRES1.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34556297.
- Also identified by DOI 10.1016/j.kint.2021.07.008 and PMC identifier 9037532.
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Abstract
Retinoic acid receptor responder protein 1 (RARRES1) has been identified as a novel gene for the regulation of podocyte function, and its expression is increased in glomerular disease and associated with disease progression. Increased expression of RARRES1 in podocytes leads to apoptosis through an autocrine effect. Möller-Hackbarth et al. recently found that RARRES1 expression is increased in the endothelial cells in some diseased kidneys to promote podocyte injury, likely through a paracrine effect.
Medical subject headings
- Kidney Diseases
- Podocytes