Complement factor H: a guardian within?
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- Record sourced from PubMed, PMID 34556298.
- Also identified by DOI 10.1016/j.kint.2021.07.023.
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Abstract
The glomerular endothelium produces the key complement regulator factor H (FH), but its role in the endothelial cells protection and functional integrity is unclear. In this edition of Kidney International, Mahajan et al. demonstrate that the endothelial-intrinsic FH is important for the cytoskeletal architecture, monolayer integrity, proliferation control, metabolism, and inflammatory signaling regulation. These findings place the endothelium-derived FH in the center of the pathological process of diseases, characterized with FH genetic abnormalities.
Medical subject headings
- Complement Factor H
- Endothelial Cells