Relationship Between <sup>18</sup>F-Flortaucipir Uptake and Histologic Lesion Types in 4-Repeat Tauopathies.
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- Record sourced from PubMed, PMID 34556525.
- Also identified by DOI 10.2967/jnumed.121.262685 and PMC identifier 9157721.
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Abstract
Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are 4-repeat (4R) tauopathies with overlapping, but also morphologically distinct, tau immunoreactive lesions that vary in count by brain region. <sup>18</sup>F-flortaucipir PET uptake has been reported to correlate with overall tau burden, and-in 1 CBD case-to have greater affinity to threads than tangles. We determined whether <sup>18</sup>F-flortaucipir uptake is associated with histologic lesion type in 4R tauopathies. <b>Methods:</b> We performed semiquantitative regional lesion counts on pretangles/neurofibrillary tangles, threads, oligodendroglial coiled bodies, tufted astrocytes, and astrocytic plaques in 29 cases of autopsied 4R tauopathy (PSP, 16; CBD, 13). Regression models were used for statistical analyses. <b>Results:</b><sup>18</sup>F-flortaucipir uptake marginally correlated with threads in the precentral cortex (<i>P</i> = 0.04) and with astrocytic lesions in the red nucleus (<i>P</i> = 0.05). <b>Conclusion:</b> The findings do not support <sup>18</sup>F-flortaucipir's having differential affinity to any 4R tau lesion type.
Medical subject headings
- Corticobasal Degeneration
- Supranuclear Palsy, Progressive
- Tauopathies