Location Matters: Profiling Diffuse Type Gastric Cancer At the Single-Cell Level.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34556549.
- Also identified by DOI 10.1158/1078-0432.CCR-21-2935 and PMC identifier 8639659.
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Abstract
Spatial single-cell transcriptomics of primary patient diffuse type gastric cancer reveals distinct cancer and stromal cell differences based on location. Expression of CCL2 by stromal cells in deep tumor regions is highlighted as potentially driving the immunosuppressive microenvironment and enhancing (directly or indirectly) the invasive capacity of tumor cells.<i>See related article by Jeong et al., p. 6529</i>.
Medical subject headings
- Stomach Neoplasms