Fat Fraction Measurements Using a Three-Material Decomposition Dual-Energy CT Technique Accounting for Bone Minerals: Evaluation in a Bone Marrow Phantom Using MRI as Reference.

Li, Baojun; Hua, Ning; Li, Janelle; Andreu-Arasa, V Carlota; LeBedis, Christina; Anderson, Stephan W · AJR Am J Roentgenol · 2022

basic_science · Level V

Where this comes from

Abstract

Conventional two-material dual-energy CT (DECT) decomposition is insufficient to model bone marrow, which contains three materials: bone minerals, red marrow (water), and yellow marrow (fat). We explore an image-domain three-material decomposition DECT technique accounting for bone minerals in a bone-water-fat phantom. Three-material decomposition fat fraction (FF<sub>3MD</sub>) exhibited stronger correlation than two-material decomposition fat fraction (FF<sub>2MD</sub>) with MRI-based fat fraction (<i>r</i> = 0.95 vs <i>r</i> = 0.69). With increasing bone minerals, correlation of FF<sub>3MD</sub> remained stable (<i>r</i> = 0.81-1.02), whereas correlation of FF<sub>2MD</sub> decreased (<i>r</i> = 0.21-0.65).

Medical subject headings