Efficacy of Prucalopride for Chronic Idiopathic Constipation: An Analysis of Participants With Moderate to Very Severe Abdominal Bloating.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 34585675.
- Also identified by DOI 10.14309/ajg.0000000000001521 and PMC identifier 8715996.
- Licence recorded as CC BY-NC-ND.
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Abstract
This post hoc analysis evaluated the effect of prucalopride on abdominal bloating in participants with chronic idiopathic constipation (CIC) who had moderate to very severe bloating at baseline. Data from 6 phase 3/4 studies of prucalopride in participants with CIC were pooled. Abdominal bloating was assessed weekly using a 5-point scale (0-4). The proportion of bloating responders (≥1-point improvement in abdominal bloating score at week 12) was higher in participants treated with prucalopride (62.1%) vs placebo (49.6%). The prucalopride arm had a higher proportion of bloating responders vs placebo in this study population.
Medical subject headings
- Abdominal Pain
- Benzofurans
- Constipation
- Pain Measurement