Exploring New Approaches for Locally Advanced Gastroesophageal Adenocarcinomas: TNT, Irinotecan, and ctDNA.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 34588214.
- Also identified by DOI 10.1158/1078-0432.CCR-21-2777 and PMC identifier 8639623.
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Abstract
The authors of a recent pilot study incorporated novel concepts including total neoadjuvant therapy with induction triplet FOLFIRINOX then chemoradiotherapy before surgery, along with ctDNA minimal residual disease analyses demonstrating both feasibility of this approach as well as confirming prognostic value of ctDNA analysis before and after surgery.<i>See related article by Wo et al., p. 6343</i>.
Medical subject headings
- Adenocarcinoma
- Pancreatic Neoplasms
- Rectal Neoplasms
- Trinitrotoluene