Antibody Deficiency, Chronic Lung Disease, and Comorbid Conditions: A Case-Based Approach.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 34592394.
- Also identified by DOI 10.1016/j.jaip.2021.09.031.
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Abstract
New emerging pulmonary phenotypes associated with antibody deficiency, such as neutrophilic asthma, frequent exacerbations of chronic obstructive pulmonary disease, and unexplained interstitial lung disease, particularly in younger adults, are discussed in this review through a case-based approach. Also discussed in similar fashion are antibody deficiency syndromes that lead to end-stage lung disease and the indications for lung transplantation in primary immunodeficiency disease. These challenging cases require timely and individualized strategies for genetic and immunologic diagnosis, decisions about therapeutic approaches, and long-term monitoring.
Medical subject headings
- Asthma
- Lung Diseases, Interstitial
- Lung Transplantation
- Primary Immunodeficiency Diseases
- Pulmonary Disease, Chronic Obstructive