Microglia esprit de corps: Sharing the burden of eliminating toxic aggregates.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 34597598.
- Also identified by DOI 10.1016/j.cell.2021.08.033.
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Abstract
Microglia play critical roles in the defense against neurodegenerative diseases. In this issue of Cell, Scheiblich et al. focus on microglia that ingest toxic aggregates of α-synuclein, finding that α-synuclein-replete microglia exchange aggregates for healthy mitochondria via nanotube connections to unaffected microglia. This communication enables a shared approach to aggregates disposal while preserving the health of the microglial population.
Medical subject headings
- Microglia
- Neurodegenerative Diseases