In vitro corrosion study of PLA/Mg composites for cardiovascular stent applications.

Abstract

The present investigation explores the impact of Mg volume fraction (V_Mg) as a controlling parameter of degradation rate in designing patient-specific cardiovascular stents made of PLA/Mg composites. For the purpose of this research, PLA/Mg composite plates containing 1, 3, 5, and 10% V_Mg are produced by melt blending and hot press molding. Characterization techniques such as scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and X-ray diffraction (XRD) are employed to study the microstructure of PLA/Mg composites. For in vitro corrosion tests, stent prototypes and composite samples are immersed in baths of simulated body fluid (SBF). According to in vitro corrosion tests, increasing V_Mg increases the corrosion rate of the composites by accelerating the corrosion of the particles and the crystalline zones surrounding them. In addition, a 2% raise in the Mg content (from 1% to 3%), increases the overall Mg weight loss by more than 4 times. Composite samples and prototype stents containing more than 5% V_Mg exhibit cracking and brittleness after 7 days of immersion in SBF. In light of the compression tests results and also the failures and cracks observed during immersions, the upper limit of Mg content for PLA/Mg stent fabrication purposes is found to be below 3%.