Fibrin gel enhances the antitumor effects of chimeric antigen receptor T cells in glioblastoma.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34613775.
- Also identified by DOI 10.1126/sciadv.abg5841 and PMC identifier 8494441.
- Licence recorded as CC BY-NC.
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Abstract
Regional delivery of chimeric antigen receptor (CAR) T cells in glioblastoma represents a rational therapeutic approach as an alternative to intravenous administration to avoid the blood-brain barrier impediment. Here, we developed a fibrin gel that accommodates CAR-T cell loading and promotes their gradual release. Using a model of subtotal glioblastoma resection, we demonstrated that the fibrin-based gel delivery of CAR-T cells within the surgical cavity enables superior antitumor activity compared to CAR-T cells directly inoculated into the tumor resection cavity.