The Gro3p factor: Restoring NAD+/NADH homeostasis to ameliorate mitochondrial disease.
other · Level V
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- Record sourced from PubMed, PMID 34614406.
- Also identified by DOI 10.1016/j.cmet.2021.09.006.
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Abstract
Leigh syndrome, a mitochondrial disease, can be modeled in mice with a deficiency in mitochondrial complex I that results in a decreased NAD+/NADH ratio. In this issue of Cell Metabolism, Liu et al. (2021) identify glycerol-3-phosphate (Gro3P) biosynthesis as a method for regenerating cytosolic NAD+ to ameliorate pathology in this mitochondrial disease model.
Medical subject headings
- Mitochondrial Diseases
- NAD