Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer: A pooled analysis of individual patient data from three randomized trials.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 34619235.
- Also identified by DOI 10.1016/j.radonc.2021.09.029.
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Abstract
We assessed the impact of different PCI fractionation schedules (30 Gy in 10 versus 15 fractions) on brain metastases-free survival (BMFS) and toxicity in stage III NSCLC. Our results suggest that 30 Gy in 10 fractions is associated with increased toxicity, while no conclusive evidence of improving BMFS was seen with this schedule.
Medical subject headings
- Brain Neoplasms
- Carcinoma, Non-Small-Cell Lung
- Lung Neoplasms
- Percutaneous Coronary Intervention