Co-targeting TGF-β and PD-L1 with radiation therapy: The Goldilocks principle.

Bakhoum, Samuel F; Rudin, Charles M · Cell Rep Med · 2021

editorial · Level V

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Abstract

In the current issue of <i>Cancer Cell</i>, Lan et al.<sup>1</sup> demonstrate that a bifunctional fusion protein targeting TGF-β and PD-L1 can synergize with radiation therapy to simultaneously augment tumor control and reduce normal tissue toxicity.

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