Phase separating cell fate.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 34624226.
- Also identified by DOI 10.1016/j.stem.2021.09.012.
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Abstract
How master regulators such as Oct4 can shape 3D genome architecture during cell reprogramming remains poorly understood. In this issue of Cell Stem Cell, Wang et al. (2021) demonstrate that Oct4 undergoes phase separation to reconfigure TAD architecture for cell fate control.
Medical subject headings
- Cellular Reprogramming
- Octamer Transcription Factor-3