Stress-responsive transcription factors train stem cells to remember.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 34624227.
- Also identified by DOI 10.1016/j.stem.2021.09.005.
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Abstract
In this issue of Cell Stem Cell,Larsen et al. (2021) reveal the molecular machinery that empowers epidermal stem cells to remember. They find that STAT3 and AP1 family establish memory, enabling JUN to remain on the open chromatin and allowing fast recruitment of FOS in case of a second attack.
Medical subject headings
- Proto-Oncogene Proteins c-jun
- Stem Cells