Defining the Healthy Infant Metabolome: Liquid Chromatography Tandem-Mass Spectrometry Analysis of Dried Blood Spot Extracts from the Prospective Research on Early Determinants of Illness and Children's Health Trajectories Birth Cohort Study.
Where this comes from
- Record sourced from PubMed, PMID 34626671.
- Also identified by DOI 10.1016/j.jpeds.2021.09.061 and PMC identifier 8838877.
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Abstract
Newborn screening using dried plasma spots offers preanalytical advantages over conventional cards for plasma-associated targets of interest. Herein we present dried plasma spot-based methods for measuring metabolites using a 250+ compound liquid chromatography tandem mass spectrometry library. Quality assurance reduced this library to 134, and from these, 30 compounds determined the normal newborn reference ranges.
Medical subject headings
- Biomarkers
- Chromatography, Liquid
- Dried Blood Spot Testing
- Metabolome
- Neonatal Screening
- Tandem Mass Spectrometry