Cardiovascular Effects of Particulate Air Pollution.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34644154.
- Also identified by DOI 10.1146/annurev-med-042220-011549 and PMC identifier 10132287.
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Abstract
Inhalation of fine particulate matter (PM<sub>2.5</sub>), produced by the combustion of fossil fuels, is an important risk factor for cardiovascular disease. Exposure to PM<sub>2.5</sub> has been linked to increases in blood pressure, thrombosis, and insulin resistance. It also induces vascular injury and accelerates atherogenesis. Results from animal models corroborate epidemiological evidence and suggest that the cardiovascular effects of PM<sub>2.5</sub> may be attributable, in part, to oxidative stress, inflammation, and the activation of the autonomic nervous system. Although the underlying mechanisms remain unclear, there is robust evidence that long-term exposure to PM<sub>2.5</sub> is associated with premature mortality due to heart failure, stoke, and ischemic heart disease.
Medical subject headings
- Air Pollutants
- Air Pollution
- Cardiovascular Diseases