Analysis of Severe Acute Respiratory Syndrome 2 Replication in Explant Cultures of the Human Upper Respiratory Tract Reveals Broad Tissue Tropism of Wild-Type and B.1.1.7 Variant Viruses.
basic_science · Level V
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- Record sourced from PubMed, PMID 34651643.
- Also identified by DOI 10.1093/infdis/jiab523 and PMC identifier 8524635.
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Abstract
The upper respiratory tract (URT) is the primary entry site for severe acute respiratory syndrome 2 (SARS-CoV-2) and other respiratory viruses, but its involvement in viral amplification and pathogenesis remains incompletely understood. In this study, we investigated primary nasal epithelial cultures, as well as vital explanted tissues, to scrutinize the tropism of wild-type SARS-CoV-2 and the recently emerged B.1.1.7 variant. Our analyses revealed a widespread replication competence of SARS-CoV-2 in polarized nasal epithelium as well as in the examined URT and salivary gland tissues, which was also shared by the B.1.1.7 virus. In our analyses, we highlighted the active role of these anatomic sites in coronavirus disease 2019.
Medical subject headings
- COVID-19
- Respiratory System
- Viral Tropism
- Virus Replication