ADAMs family in kidney physiology and pathology.
Where this comes from
- Record sourced from PubMed, PMID 34653870.
- Also identified by DOI 10.1016/j.ebiom.2021.103628 and PMC identifier 8517843.
- Licence recorded as CC BY-NC-ND.
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Abstract
A disintegrin and metalloproteinases (ADAMs) family are proteolytic transmembrane proteases that modulate diverse cell functions and coordinate intercellular communication. ADAMs are responsible for regulating cell proliferation, differentiation, migration, and organ morphogenesis in kidney development. Abnormally activated ADAMs drive inflammation and fibrosis in response to kidney diseases such as acute kidney injury, diabetic kidney disease, polycystic kidney disease, and chronic allograft nephropathy. ADAM10 and ADAM17, known as the most characterized members of ADAMs, are extensively investigated in kidney diseases. Notably, ADAM proteases have the potential to be targets for developing novel treatment approaches in kidney diseases.
Medical subject headings
- ADAM Proteins
- Kidney
- Kidney Diseases