Decrease in pain perception during acute SARS-CoV-2 infection: a case series.

Hentsch, Lisa; Stancu, Patrick; Allali, Gilles; Lövblad, Karl-Olof; Lobrinus, Johannes A; Cocetta, Sara; Pautex, Sophie; Uginet, Marjolaine et al. · Pain · 2022

case_series · Level IV

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Abstract

Many reports have described pain appearance or an increase of chronic pain concomitant to severe acute respiratory syndrome coronavirus 2 infection. Here, we describe the cases of 3 patients with chronic cancer pain, in which COVID-19 was associated with a dramatic reduction or disappearance of pain. Pain reappeared after recovery from COVID-19. Neurological imaging and pathological findings, when available, were inconclusive. To the best of our knowledge, this is the first case series reporting an acute reduction in pain perception in COVID-19. We believe further investigation is mandatory because it could shed new light on the mechanisms of pain perception and modulation.

Medical subject headings