Elevated jugular venous oxygen saturation after cardiac arrest.

Abstract

We performed a retrospective analysis of our earlier study on cerebral oxygenation monitoring by jugular venous oximetry (SjvO₂) in patients of out-of-hospital cardiac arrest (OHCA). The study was focused on high SjvO₂ values (≥75%) and their association with neurological outcomes and serum neuron-specific enolase (NSE) concentration. Forty OHCA patients were divided into (i) high (Group I), (ii) normal (Group II), and (iii) low (Group III) SjvO₂, with the mean SjvO₂ ≥ 75%, 55-74% and <55% respectively. The neurological outcome was evaluated using the Cerebral Performance Category scale (CPC) on the 90th day after cardiac arrest (post-CA). NSE concentration was determined after ICU admission and then at 24, 48, and 72 hours (h) post-CA. High mean SjvO₂ occurred in 67% of patients, while no patients had low mean SjvO₂. The unfavourable outcome was significantly more common in Group I than Group II (74% versus 23%, p < 0.01). Group I patients had significantly higher median NSE than Group II at 48 and 72 h post-CA. A positive correlation was found between SjvO₂ and PaCO₂. Each 1 kPa increase in CO₂ led to an increase of SjvO₂ by 2.2 %+/-0.66 (p < 0.01) in group I and by 5.7%+/-1.36 (p < 0.0001) in group II. There was no correlation between SjvO₂ and MAP or SjvO₂ and PaO₂. High mean SjvO₂ are often associated with unfavourable outcomes and high NSE at 48 and 72 hours post-CA. Not only low but also high SjvO₂ values may require therapeutic intervention.