Generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34686685.
- Also identified by DOI 10.1038/s41467-021-26380-y and PMC identifier 8536768.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Tumor response to radiotherapy or ferroptosis is closely related to hydroxyl radical (•OH) production. Noninvasive imaging of •OH fluctuation in tumors can allow early monitoring of response to therapy, but is challenging. Here, we report the optimization of a diene electrochromic material (1-Br-Et) as a •OH-responsive chromophore, and use it to develop a near-infrared ratiometric fluorescent and photoacoustic (FL/PA) bimodal probe for in vivo imaging of •OH. The probe displays a large FL ratio between 780 and 1113 nm (FL<sub>780</sub>/FL<sub>1113</sub>), but a small PA ratio between 755 and 905 nm (PA<sub>755</sub>/PA<sub>905</sub>). Oxidation of 1-Br-Et by •OH decreases the FL<sub>780</sub>/FL<sub>1113</sub> while concurrently increasing the PA<sub>755</sub>/PA<sub>905</sub>, allowing the reliable monitoring of •OH production in tumors undergoing erastin-induced ferroptosis or radiotherapy.
Medical subject headings
- Hydroxyl Radical
- Molecular Imaging
- Molecular Probes
- Neoplasms
- Optical Imaging