Telomere length and chronic kidney disease: cause or consequence?
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Where this comes from
- Record sourced from PubMed, PMID 34688387.
- Also identified by DOI 10.1016/j.kint.2021.08.013.
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Abstract
Telomere length is considered as a clock mirroring aging and is influenced by oxidative stress and inflammation. Both conditions are highly prevalent in patients with chronic kidney disease and other degenerative disorders, such as cardiovascular disease. However, it is discussed controversially whether short telomeres are causally associated with chronic kidney disease or whether chronic kidney disease is contributing to an attrition of telomere length. Park et al., in this issue of Kidney International, use an extended 2-sample Mendelian randomization analysis with large data sets to shed new light on this research question.
Medical subject headings
- Renal Insufficiency, Chronic
- Telomere